Ligandrol (LGD-4033) – It’s Role In The Madness
A super bout between Nate Diaz and Jorge Masvidal was on the verge of falling through. Nate Diaz a.k.a “The Baddest Mother F***er’ gained a decision victory over Anthony Pettis in August. His opponent, Jorge Masvidal, gained traction after brutally knocking out Ben Askren. This earned Masvidal the “fastest knockout in UFC history” title. However, the event was in jeopardy after Nate announced his withdrawal. Confusion spread through the MMA community as to why Nate would pull out of such an event.
In the following hours, it came to light that Nate had failed a USADA drug test. The test had shown traces of LGD-4033 also known as Ligandrol. Diaz, a devout vegan, attributed the reading to plant-based vegan multivitamins. Nate went on to release a statement on twitter explaining the situation with a tweet titled “Your all on steroid not me”. Nevertheless, Nate’s story checked out as the plant based multivitamin matched with the traces detected.
But this begs the question, Was Nate Diaz actually supplementing SARMs? Furthermore, what benefit would an MMA athlete gain from a SARM such as Ligandrol (LGD-4033)?
What is Ligandrol?
Ligandrol also referred to as LGD-4033 or Anabolicum, is a Selective Androgen Receptor Modulator (SARM). Ligand Pharmaceuticals, a research company based in San Diego, USA developed the compound. However, Viking Therapeutics currently owns the licensing. The main reason behind the development of this compound was to fight muscle dystrophy. A muscle wasting condition caused by diseases such as cancer and HIV.
How Does Ligandrol Work?
Androgen receptors are a type of nuclear receptor activated through the binding of androgenic hormones. Binding results in the up-regulation of androgen genes. Ultimately, this contributes to the maintenance and development of the male sexual phenotype. Endogenous ligands for the androgen receptors are testosterone, dihydrotestosterone. However, Ligandrol is synthetic ligand with a specific affinity towards androgen receptors in muscle and bone. As a result, it is able to induce anabolic effects with minimal androgenic effects.
Why use Ligandrol?
There are two main reasons as to why an athlete would consider supplementing LGD-4033:
- Increased muscle mass.
- Increased healing properties.
Ligandrol Muscle Mass Gains
LGD-4033 boasts the ability to increase muscle mass significantly. In any sport, having more muscle mass is favourable. In MMA specifically, improving strength can help you take down and wrestle opponents much easier. A clinical trial conducted on 76 healthy males showed Ligandrol to boost muscle strength and improve lean body mass. During the double blind trial, a safe and favourable pharmacokinetic profile was also observed without changes in prostate-specific antigen. Within the 3 weeks, subjects gained 1.21kg of lean body mass (Basaria S, et al., 2013). An average strength increase of 68.3N complemented this also.
In combat sports, athlete’s endure long hard camps to ensure they make weight for the fight. To cut significant weight, fighters enter a massive caloric deficit and partake in strenuous cardio sessions. Consequently, individuals enter a catabolic state where the body begin to break down muscle. Athletes try really hard to preserve hard earned muscle through strength training. Muscle retention can massively improved through the use of SARMs such as Ligandrol. Furthermore, LGD-4033 helps athletes gain lean muscle mass. It is obvious to see why this is a popular substance amongst professional sportspeople.
Other Uses of Ligandrol
Fractures and broken bones are commonplace within the world of MMA. To ensure longevity, athletes maintain a healthy diet along with effective supplementation. LGD-4033 has favourable properties in improving bone health. Due to the design of the compound, it is effective at targeting androgen receptors within bone. As a result, it promotes bone formation and combats bone loss. In a 2018 clinical trial, subject recovering from hip surgery were supplemented with Ligandrol. When compared to the control group, individuals who supplemented Anabolicum could walk further and exhibited an increase in muscle mass (Viking, 2018).
Effective Ligandrol Dosage
Throughout the clinical trials, the dosages of LGD-4033 have varied. Due to it’s strength, the effects of this substance are evident at small dosages starting from 1mg. There have been reports of athletes supplementing with 20mg but the recommended dosage for optimal effects has been rumoured to be within the 5-10mg region.
Where to Buy Ligandrol
Various online sellers claim to sell LGD-4033 but fail to provide COA and HPLC testing certificates. Purchasing from these vendors can be a risky investment. Phlex Labs stocks only the high purity research chemicals and SARMs from audited manufacturers. They follow strict manufacturing guidelines to ensure product safety and purity. Click on the image below to purchase our Ligandrol our browse through our wide collection of SARMs and research chemicals.
Although Nate has been cleared of doping charges, it is clear to see why any athlete would consider Ligandrol as a supplement of choice. Through clinical trials, it’s ability to improve muscle mass and strength are very pronounced. Using LGd-4033 could help a fighter to out-muscle his opponent. Additionally, it could help to prevent career ending injuries such as broken bones which occur frequently in MMA.